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M94A2655.TXT
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1994-10-25
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Document 2655
DOCN M94A2655
TI Diagnosis of perinatally acquired HIV-1 infection by IgA EIA test.
DT 9412
AU Liberatore D; Avila M; Calarota S; Libonatti O; Martinez Peralta L;
National Reference Centre for AIDS, Buenos Aires, Argentina.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):255 (abstract no. PB0450). Unique
Identifier : AIDSLINE ICA10/94369920
AB OBJECTIVE: To evaluate the clinical utility of detection of anti-HIV-1
IgA antibody by a serological assay for the early diagnosis of
perinatally acquired HIV-1 infection. METHODS: Sera were obtained from
45 infants born to HIV-1 infected mothers and tested for HIV IgA
antibodies by an ELISA test after removal of IgG with recombinant
protein G. Infants were classified according to age and infection status
after 15 months of age; 24 were classified as HIV infected children and
21 as uninfected (CDC, 1987). RESULTS: The HIV-IgA assay was positive in
15 infected children between 6 and 12 months and in 6 infected children
older than 12 months but under 18 months. Nineteen serum samples from
uninfected children under 15 months of age were negative by the HIV-1
IgA assay. False negative results were found in 3 infected children of
1, 6 and 8 months of age. False positive results were found in 2
uninfected children of 8 and 9 months of age. CONCLUSIONS: The detection
of IgA HIV antibodies is an effective method for early diagnosis of
HIV-infected infants in comparison with conventional IgG HIV antibody
tests. It is a simple and inexpensive method that could be used in both
developed and developing countries.
DE Argentina AIDS Serodiagnosis/*METHODS *Developing Countries Female
Follow-Up Studies Human HIV Antibodies/*BLOOD HIV
Seropositivity/*DIAGNOSIS/IMMUNOLOGY/TRANSMISSION HIV-1/*IMMUNOLOGY
IgA/*BLOOD *Immunoenzyme Techniques Infant Infant, Newborn Male
Predictive Value of Tests Pregnancy MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).